In vitro evaluation of novel designed, and synthesized naproxen derivatives bearing 1,2,4 triazole moiety

The Objective of this study is created a novel derivative the naproxen with heterocyclic (1,2 and 4 triazole) ring that reacted benzoyl chloride derivatives, as well preliminary antibacterial activity testing formed products. derivatives are synthesized by esterifying hydrazine hydrate, then reacting hydrated carbon disulfide, finally reaction (in final step) triazole including amino group via nucleophilic substitution reaction. In addition to naproxen, properties compounds (Va-Vd) were evaluated in agar at known doses (IN vivo). action Va Vd against staph was demonstrated topmost inhibited zone. case E. coli, compound Vb has smallest inhibitory findings have implications produce 1,2 triazole-three-thiol which variety derivatives. potential will be affected attraction para-groups on benzen ring.